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Search Results for " breast cancer resistance protein "

17

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0186	Ko 143	BCRP; ABC	Membrane transporter/Ion channel
	Ko 143 有效且选择性抑制 ATP 结合盒亚家族 G 成员 2 (ABCG2/BCRP)
T3581	KS176	Potassium Channel; BCRP	Membrane transporter/Ion channel
	KS176是选择性高活性乳腺癌耐药蛋白多药转运通道抑制剂，在Pheo A 和Hoechst 检测中，IC50值分别为0.59和1.39 μM。
T4595	YHO-13177 YHO 13177,YHO13177	BCRP	Membrane transporter/Ion channel
	YHO-13177 是高活性乳腺癌耐药蛋白多药转运通道（BCRP）抑制剂，可增强SN-38活性。
T38400	Triclabendazole sulfoxide TCBZ-SO,三氯苯达唑亚砜	BCRP; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	Triclabendazole sulfoxide (TCBZ-SO) 是 Triclabendazole 的主要血浆代谢产物。Triclabendazole sulfoxide 具有抗寄生虫活性。Triclabendazole sulfoxide 可以抑制膜转运蛋白ABCG2/BCRP 的活性。
T13383	Zamicastat BIA 5-1058	BCRP; Hydroxylase; P-gp	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Zamicastat (BIA 5-1058) 是多巴胺 β-羟化酶 (DBH) 抑制剂，可透过血脑屏障引起中枢和周边效应，具有降血压作用。它也是一种浓度依赖性的双重 P-gp 和 BCRP 抑制剂，IC50值分别为 73.8 和 17.0 μM。
T4337	PCI 29732 PCI29732,PCI-29732	Others; BCRP; BTK	Angiogenesis; Membrane transporter/Ion channel; Others; Tyrosine Kinase/Adaptors
	PCI 29732 是一种有效的可逆BTK 抑制剂，对 BTK、Lck 和 Lyn 的Kiapp 值分别为 8.2、4.6 和 2.5 nM。它通过竞争性结合ABCG2 的 ATP 结合位点来抑制ABCG2的功能。
T83892	33-BCRP Inhibitor 33-Breast Cancer Resistance Protein Inhibitor
	33-BCRP抑制剂是一种乳腺癌耐药蛋白(BCRP)的抑制剂。它使得对米托蒽醌耐药的H460/MX20肺癌细胞对米托蒽醌诱导的细胞死亡更加敏感，无论是单独使用还是与UV辐射联合使用。33-BCRP抑制剂还能够增强表达P-糖蛋白(P-gp，亦称为多药耐药蛋白MDR)的KB-C2表皮癌细胞对秋水仙碱诱导的细胞死亡的敏感性。当使用5 µM浓度时，它能增加米托蒽醌在H460/MX20细胞中的细胞内积累。
T2657	Elacridar GW0918,依克立达,GW120918,GF120918,GG918	BCRP; P-gp	Membrane transporter/Ion channel; Neuroscience
	Elacridar (GG918) 是一种有效的 P-糖蛋白和BCRP 的抑制剂。
T6200	Ledipasvir GS-5885,雷迪帕韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Ledipasvir (GS-5885) 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。
T10490	(S)-ML753286	Others	Others
	(S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor (IC50: 0.6 μM on BCRP efflux transporter).
T37685	CAY10719 CAY10719
	CAY10719 is a selective inhibitor of the breast cancer resistance protein ABCG2 (IC50 = 0.23 μM) with little activity at ABCG1. It has been shown to reverse the ABCG2-mediated resistance toward SN 38 and to inhibit ATPase activity.
T14340	Atiratecan TP300	Others	Others
	Atiratecan (TP300) is a prodrug of camptothecin analog CH0793076. Atiratecan shows antitumor activity against both breast cancer resistance protein (BCRP)-positive and -negative xenografts in mouse xenograft models[1]. Atiratecan does not inhibit acetylch
T14945	CH-0793076 TP3076	Topoisomerase	DNA Damage/DNA Repair
	CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM).
T73356	Ac32Az19
	Ac32Az19 是一种有效、无毒、高选择性的 BCRP 抑制剂，在BCRP 过度表达的HEK293/R2细胞中，EC50值为13 nM。
T73672	CH-0793076 TFA
	CH-0793076 (TP3076) TFA，喜树碱的六环类似物，是 TP300 的活性药物和主要代谢物。CH-0793076 TFA 抑制 DNA 拓扑异构酶 I (DNAtopoisomeraseI)，IC50为 2.3 μM。CH-0793076 TFA 对表达 BCRP(乳腺癌耐药蛋白) 的细胞也有活性。
T72861	(6R)-ML753286
	(6R)-ML753286 是 ML753286 的异构体。ML753286 是一种口服活性和选择性 BCRP(抗乳腺癌蛋白) 抑制剂，IC50为 0.6 μM。 ML753286 在啮齿动物和人类肝脏 S9 组分中具有高渗透性和低至中等清除率，并且在不同物种中都具有血浆稳定性。
T36807	Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
	Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 ...

化合物

Cat.No: TQ0186

Target: BCRP, ABC

Cat.No: T3581

Target: Potassium Channel, BCRP

Cat.No: T4595

Synonym: YHO 13177,YHO13177

Target: BCRP

Triclabendazole sulfoxide

Cat.No: T38400

Synonym: TCBZ-SO,三氯苯达唑亚砜

Target: BCRP, Parasite

Cat.No: T13383

Synonym: BIA 5-1058

Target: BCRP, Hydroxylase, P-gp

Cat.No: T4337

Synonym: PCI29732,PCI-29732

Target: Others, BCRP, BTK

33-BCRP Inhibitor

Cat.No: T83892

Synonym: 33-Breast Cancer Resistance Protein Inhibitor

Cat.No: T2657

Synonym: GW0918,依克立达,GW120918,GF120918,GG918

Target: BCRP, P-gp

Cat.No: T6200

Synonym: GS-5885,雷迪帕韦

Target: HCV Protease, SARS-CoV

Cat.No: T10490

Target: Others

Cat.No: T37685

Synonym: CAY10719

Cat.No: T14340

Synonym: TP300

Target: Others

Cat.No: T14945

Synonym: TP3076

Target: Topoisomerase

Cat.No: T73356

Cat.No: T73672

Cat.No: T72861

Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)

Cat.No: T36807

Cat. No.	Product Name	Target	Signaling Pathways
TN3150	6,8-Diprenylnaringenin 6,8-二异戊二烯基柚皮素,Senegalensin,Lonchocarpol A	BCRP; ABC	Membrane transporter/Ion channel
	6,8-Diprenylnaringenin (Senegalensin) 是来自蛇麻草 Humulus lupulus 的天然产物。 6,8-Diprenylnaringenin 是一种乳腺癌耐药蛋白 (BCRP) 抑制剂，具有一定雌激素作用。
T15355	Fumitremorgin C 烟曲霉毒素c,12α-Fumitremorgin C	BCRP; Antibacterial; Antibiotic; ABC	Membrane transporter/Ion channel; Microbiology/Virology
	Fumitremorgin C (12α-Fumitremorgin C) 是ABCG2/BRCP 的选择性抑制剂。
T3208	Brevianamide F Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)	BCRP; PI3K; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Brevianamide F (Cyclo(L-Pro-L-Trp)) 是一种从Colletotrichum gloeosporioides 中分离得到的真菌毒素，属于天然存在的 2,5-二酮哌嗪类，具有抗菌活性。它具有PI3Kα抑制活性，IC50值为 4.8 µM。
TN5190	Tryprostatin A	Topoisomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at the G2/M phase.

天然产物

6,8-Diprenylnaringenin

Cat.No: TN3150

Synonym: 6,8-二异戊二烯基柚皮素,Senegalensin,Lonchocarpol A

Target: BCRP, ABC

Fumitremorgin C

Cat.No: T15355

Synonym: 烟曲霉毒素c,12α-Fumitremorgin C

Target: BCRP, Antibacterial, Antibiotic, ABC

Cat.No: T3208

Synonym: Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp)

Target: BCRP, PI3K, Antibacterial

Cat.No: TN5190

Target: Topoisomerase, Antifection

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